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Description
Higher doses also amplify semaglutide's effects on nutrient absorption and energy expenditure at the cellular level

This rebound is driven by metabolic adaptation, restoration of appetite hormones, and reduced insulin sensitivity rather than behavioral failure alone

Na, Janine, and Thomas Efferth
The net effect is better blood sugar control and less hunger
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If testosterone therapy is started in a patient on a blood thinner, more frequent monitoring of coagulation (e.g., INR) and dose adjustments of the anticoagulant may be necessary
