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Yet the substantia nigra dopaminergic neuron is also a metabolically stressed cell type whose autonomous activity, calcium handling, and large axonal arbor place unusual demands on linked purposeful movement, reinforcement, and cellular energetic support becomes progressively unstable
10.1056/NEJMoa1310799
The effects increased with higher doses
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Refrigerate as soon as possible, and this window should only be relied upon during unavoidable circumstances like delayed luggage or broken cooling equipment

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