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Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy

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The patterns of relative activity among ACPC-containing analogues of GLP-1 and exendin-4 support the hypothesis that access to non-helical conformations near the agonist N-terminus is important for GLP-1R activation

Clinical trials show constipation occurs in approximately 11-24% of patients taking semaglutide and 6-11% taking tirzepatide, compared to 11% in placebo groups

Weight loss is never sustained and weight gain after weight loss keeps happening such that the individuals weight moves up and down like a yo-yo