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revenues with LOE in 2028-2029 and assuming 80 percent revenue erosion over three years post-LOE, the NPV of the formulation patent protection from 2026 to 2028 (the period beyond the compound patent expiry) is approximately $16 billion to $20 billion at a 10 percent discount rate

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Structural damage to testicular tissue Damage to seminiferous tubules Diabetic patients frequently show significant structural damage in seminiferous tubules, including atrophy, thinning, disorganized epithelial cells, and reduced spermatogenic cell counts [47, 48]