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J Am Coll Cardiol (2006) 47(8 Suppl):C712

There may be some evidence, though questionable, that active ingredients like berberine and green tea might curb cravings and reduce appetite a bit , but the effects are not dramatic enough for this to be an FDA-approved strategy. In other words, the patches are likely much ado about nothing

Hinojosa says

For most people, this is right in the morning after they wake up

However, a systematic review in 2023 found only one phase 2 randomized controlled trial of exenatide versus placebo for IIH, which did demonstrate a significant reduction in ICP at all time points, as well as improved headache and visual acuity (7,8)

Nonetheless, market growth will require a combination of effectiveness, tolerability, safety, acceptability among payers, and proof of cardiometabolic benefits