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CummingsDEWeigleDSFrayoRSBreenPAMaMKDellingerEPet al

Despite the accumulating evidence around pathways engaged by the GLP-1R and other GPCRs in target tissues, there is still substantial uncertainty about the precise molecular mechanisms involved, particularly with regards to the spatiotemporal organisation of their signalling and their presence in spatially restricted subcellular (or even suborganelle) signalling hubs or nanodomains 61

[DOI] [PubMed] [Google Scholar] 10.Brubaker PL, Crivici A, Izzo A, Ehrlich P, Tsai CH, Drucker DJ

Breaking the cycle requires addressing both the hormonal deficit and the excess fat simultaneously

This observation touches on an important shift occurring alongside the development of these drugs: a changing understanding of obesity