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GLP-1 signaling has been shown to inhibit activation of the NLRP3 inflammasome, a key driver of innate immune-mediated inflammation, and to enhance Treg activity, suggesting a broader role in restoring immune tolerance [26,27]

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Compared to insulin therapy, 57 and 30 patients would need to be treated with a GLP-1RA over a mean of 2.3 years to prevent one case of all-cause mortality and hospitalized hypoglycemia, respectively

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