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Given the substantial weight loss retatrutide produces, it is plausible that nutritionally driven hair shedding may occur in some individuals though this should be understood as a hypothesis based on the known effects of rapid weight loss rather than a confirmed drug-specific effect

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Moreover, gastric distension stimulates vagal mechanoreceptors, predominantly located in the proximal and distal stomach, and lastly, increases c-Fos levels in NTS neurons expressing GLP-1 and GLP-2 in rats [178]

A pilot functional MRI study in Roux-en-Y gastric bypass patients to study alteration in taste functions after surgery

severe or persistent upper abdominal pain should prompt urgent medical assessment [10] [11] Dehydration and acute kidney injury (AKI): gastrointestinal fluid losses can lead to dehydration, which may precipitate AKI, particularly in those with pre-existing renal impairment or those taking nephrotoxic medicines Delayed gastric emptying: this may affect the absorption of orally administered medicines, including contraceptive pills and thyroid replacement therapy [11] Injection site reactions: redness, bruising, or discomfort at the subcutaneous injection site Heart rate changes: increases in resting heart rate have been noted with GLP-1 class agents [14] [15] Hypoglycaemia: particularly if used alongside insulin or sulphonylureas Potential pancreatitis risk: a class concern with GLP-1 receptor agonists

To his surprise, he could barely feel it