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GLP-1RAs, particularly liraglutide, can modulate this pathway in disease-specific contexts: In neonatal hypoxic-ischemic brain injury models, liraglutide activates PI3K/Akt signaling, reducing neuronal apoptosis and improving long-term cognitive outcomes (Zeng et al., 2019

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But theres a likely biological explanation

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Retatrutide decreased mean SBP by up to 12.1 mmHg in persons with overweight/obesity not having uncontrolled hypertension [50], improving on results reported for tirzepatide [51] and semaglutide [52]

Finally, its important to note that making dietary changes to boost GLP-1 release is likely not comparable to the effectiveness of GLP-1 receptor agonist medications like semaglutide