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Report any suspected side effects to your healthcare professional and consider using the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

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Constipation (2030%) From slowed GI motility

The resource includes step-by-step instructions for each process, definitions, contact information, and more

Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks

Typically, cagrilintide peptide doses are carefully tailored, often starting low to reduce gastrointestinal discomfort