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This may be similar to patients with diabetes with lower HbA1c having less change than those with higher HbA1c with anti-diabetes medications which dont cause hypoglycemia

Small studies have suggested a parallel reduction in intrapancreatic fat content following initiation of GLP-1RA 52

Additionally, ongoing studies suggest that GLP-1 medications may benefit conditions such as non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) by improving insulin sensitivity, reducing inflammation, and positively influencing metabolism

Huo YR, Suriyaarachchi P, Gomez F, Curcio CL, Boersma D, Gunawardene P, et al

Supporting a role of the NTS in mediating GLP-1's effects on food intake, adeno-associated virus (AAV) mediated knock-down of GLP-1R in the NTS results in higher food intake and meal size [699]