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Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

The identified proteases responsible for its rapid decay are DPP-4 (dipeptidyl peptidase-4) 34 , which cleaves selectively between residues 2 and 3, and NEP 24.11 35 , which cleaves at multiple sites

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