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Posttranslational processing of preproglucagon The vast majority of glucagon is produced in the pancreatic -cells, but, under some conditions, small amounts of glucagon also have been detected in the intestinal L-cells [87], although the validity of immunoassays to distinguish different proglucagon products has been questioned, and some reports were unable to find genuine glucagon in the intestine by mass spectrometric analysis [[144], [145], [146]]

Van Bloemendaal L, IJzerman RG, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML, et al

Table 5 summarizes the results from cardiovascular studies

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Hypoglycemia: Low blood sugar is more common when taking a GLP-1 with insulin or a sulfonylurea