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Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

However, for the GLP-1-Am (2, -Glu-palm) analogue, the lipidation site close to N-terminal region of GLP-1 drastically decreased the peptide solubility, limiting it to pH 3, and resulted in the rapid aggregation into amyloid-like fibrils making this analogue unsuitable for further development

Healthy fats , especially monounsaturated and omega-3 fatty acids, also promote GLP-1 secretion

10.1016/j.autrev.2011.11.014 8 DellapasquaS.ColleoniM

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