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GLP-1 medications like semaglutide and tirzepatide show mixed effects on gastrointestinal symptoms, with potential benefits for some IBS patients but also the risk of worsening symptoms in others

In the Evaluate Renal Function With Semaglutide Once Weekly (FLOW) trial, semaglutide reduced the risk of major kidney and cardiovascular (CV) outcomes and all-cause mortality in people with type 2 diabetes (T2D) and chronic kidney disease (CKD)

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Over time, repeated exposure trains the brain's reward pathways to prioritise these foods, generating cravings that are experienced independently of true physical hunger