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58 GLP-2 The primary physiological effect of GLP-2 appears to be within the intestine, where GLP-2 promotes small and large intestinal growth through stimulating cell proliferation and inhibiting apoptosis in the crypt compartment

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Additional hypotheses include the rapid correction of glycemia following GLP-1 RA administration, similar to the exacerbation of DR, as well as long-term effects of prior hyperglycemia via persistent changes in endothelial gene expression, often referred to as glucose memory [198,199]

Glucose-Dependent: The response only occurs after a meal when blood sugar levels rise to reduce the chance of hypoglycemia occurring