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Some of the most common or potential side effects include: Nausea Constipation Vomiting Diarrhea Abdominal Pain Headache Indigestion Dizziness Back Pain Increased Lipase or Amylase Altered Taste Nasopharyngitis (common cold) Passing Gas Bloating Belching Gastroenteritis Decreased Appetite Fatigue Gastroesophageal Reflux Disease Low Blood Sugar (hypoglycemia) in those with type II diabetes Upset Stomach These symptoms often subside as your body adjusts to the medications

Kramer CM, Borlaug BA, Zile MR, Ruff D, DiMaria JM, Menon V, et al

Weight Watchers is generally easier to start, since people can enroll online within a few seconds

The GIP component amplifies insulin release and may reduce GLP-1-related nausea a key tolerability advantage over pure GLP-1 agonists like semaglutide

Signs of pancreatitis (severe upper abdominal pain radiating to the back, accompanied by nausea and vomiting) require emergency care

Gallbladder Disease Gallstones and gallbladder inflammation have been reported, particularly in patients experiencing rapid weight loss