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Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target mendelian randomization and clinical trials

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Exenatide weekly, Liraglutide &Dulaglutide have the most reduction effect on HbA1c ( Table 3 ) Table 3: GLP-1RAs summary of head-to-head clinical trials

Robust demand in key markets such as the US, Europe and China further contributed to its strong performance

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Randomized controlled trials before the issue of CVOTs by the FDA in 2008 mainly focused on the efficacy of the blood glucose-lowering effects and a broad spectrum of adverse effects, with limited numbers of cardiovascular adverse events and relatively short follow-up duration