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For most adults with newly diagnosed type 2 diabetes without cardiorenal disease, metformin plus lifestyle modification remains initial therapy, with GLP-1 agonists as preferred second-line agents

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CagriSema pairs cagrilintide with semaglutide (a single-receptor GLP-1 drug)

Conclusions Among adults with HIV on ART and lipohypertrophy, semaglutide (GLP-1) slowed DNA methylation aging across PCGrimAge, PhenoAge, DunedinPACE, and organ clocks, while IC was unchanged

The study didn't rely on a single experiment

Multiple cardiovascular markers improved across groups