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Ocular complications from glucagon-like peptide-1 receptor agonists: Clinical evidence, potential mechanisms, and clinical recommendations

Tirzepatide itself is a powerful metabolic agent
If you find yourself consistently wanting to inject early, the better approach is to officially change your injection day and maintain a consistent 7-day rhythm from that new starting point

Kroes M, Osei-Assibey G, Baker-Searle R, Huang J

Mild redness and itching at the injection site are common and typically resolve within a few hours to a couple of days