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Compounded Medication Disclosure: Compounded medications discussed in this article - including compounded semaglutide and compounded tirzepatide - are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality before marketing

Who prescribes GLP-1 medications

The clinical trials, called LEAD, SUSTAIN, PIONEER, STEP, and SURPASS (youve got to just love the creative acronyms!) have generated data that are hard to dismiss: Glycemic Control : These drugs consistently outperform most oral antidiabetics in lowering blood sugar by 10 to 20 percent

The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo

GLP-1 agonists such as Wegovy (semaglutide) and Zepbound (tirzepatide) have demonstrated up to 20% body weight reductions in pivotal trials an efficacy previously thought achievable only through bariatric surgery

We assessed the quality of the studies with the risk of bias assessment tool for randomized controlled trials and the Risk of Bias in Non-randomized Studiesof Interventions (ROBINS-I) tool for nonrandomized trials