types of glp 1 receptor agonists Classification currently available glucagon-like peptide-1 Frontiers | Clinical perspectives on

GLP-1 receptors exist in both human and mouse macrophages [84,85]

doi: 10.1093/ecco-jcc/jjae160 100 SehgalPLichtensteinGRKhannaTProfkaKPickett-BlakelyONandiNet al

Reassuring clinical data are starting to accrue: two multinational population-based cohort studies found no increased risk of major congenital malformations, live births, pregnancy losses, and pregnancy terminations during the periconceptional period with GLP-1 RAs [139]

Although is there much benefit for monthly dosing over weekly

Newer agents tend to produce greater glucose lowering and weight loss, but may also cause more gastrointestinal symptoms during dose escalation

Also, anti-proliferative effects on smooth muscle cells and anti-inflammatory effects on macrophages may contribute to the protection against the development and progression of atherosclerosis [8-10]