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Specifically, when TOFO was administered as the first-line therapy and PIO was subsequently added, the combination showed significant additional improvements of MRI-PDFF and ALT concentrations vs

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For example, when assessing maximal cAMP efficacy as (h.m/c.m.) relative to native glucagon (100%/100%), [dGln3]glucagon (85%/30%) demonstrates preference for the hepatic GcgR while retaining 75% in vivo glycogenolytic activity [149]

Source: Heymsfield et al., JAMA, 2021

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However, long-term use involves: Monitoring for side effects: Common side effects include nausea, diarrhea, and injection site reactions