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In the UK, NICE recommends GLP-1 receptor agonists as second- or third-line treatment options for type 2 diabetes when metformin and other oral agents have not achieved adequate control (NICE NG28)

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Key variants including GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, and MC4R rs17782313 help identify whether a patient will respond optimally to semaglutide injection, oral semaglutide, tirzepatide, or combination therapy

Calocurb is also not indicated for patients with type 1 diabetes mellitus

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Renal expression of rGLP-1 has not been fully characterized due to insufficient specificity and sensitivity of the antibodies used, although it have been non-uniformly detected in endothelial cells, macrophages, juxtaglomerular cells and proximal tubule in several animal models and human tissue