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For these reasons, the development of effective treatments for MASLD that improve survival by reducing both hepatic and extrahepatic complications is a significant and partly unmet clinical need

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3.4 Chronic viral hepatitis (HBV and HCV) While HBV and HCV are primarily known as infectious diseases, their persistent presence induces profound metabolic reprogramming specifically within the host liver cells (hepatocytes), which contributes significantly to the risk of advanced liver disease and HCC ( HCV infection is strongly associated with systemic insulin resistance and T2DM ( Furthermore, HCV directly alters hepatic lipid metabolism in a way that mimics and exacerbates hepatic steatosis