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Evidence from randomized controlled trials suggests that OA-related knee pain and function improve with semaglutide but not with liraglutide treatment, and observational studies suggest that GLP-1RA use reduces the risk of surgery for knee OA

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95,96 Pharmacological agents such as GLP-1 RAs mimic endogenous GLP-1 regulatory activities, aiding in T2D management by increasing the incretin effect, postprandial insulin release, increased satiety, and decreased glucagon secretion, thus improving glycemic control

the DPP-4 cohort

However, other studies on these cell lines do not share this view
