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Wegovy semaglutide is now available as a once-daily tablet with no injections

In a pediatric population with limited treatment options beyond metformin and insulin, this represents a real therapeutic advancement for an underserved group

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Aims/hypothesis Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) have been shown to improve glycaemic management in both mice and humans

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GLP-1 medications like semaglutide and tirzepatide show mixed effects on gastrointestinal symptoms, with potential benefits for some IBS patients but also the risk of worsening symptoms in others