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The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial

This effect is a result of peripheral and central GLP-1 receptor activation, and is afforded by the ability of GLP-1 RAs to cross the blood brain barrier (BBB) [130]

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doi: 10.1016/j.metabol.2016.02.002

Mering and Minkowski's findings encouraged Gustave-douard Laguesse, a French histologist and pathologist, to theorise in 1893 that the pancreatic islets described by Langerhans produced an endocrine secretion (Hoet)