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Patients can expect comparable metabolic effects and weight reduction outcomes when using either formulation at equivalent doses
In addition, structural and functional alterations in gastric smooth muscle may contribute: in the gastric fundus, impaired inhibitory neurotransmission is accompanied by reduced tonic contraction because of defective muscle contractility, whereas in the antrum both cholinergic neuromuscular transmission and smooth muscle strength are altered [19, 23, 42, 43]
Footnotes DISCLOSURE: The author declares no conflict of interest References 1.Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, et al
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Sotagliflozin and Kidney Outcomes, Kidney Function, and Albuminuria in Type 2 Diabetes and CKD: A Secondary Analysis of the SCORED Trial
