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Anti-obesity drugs should be offered as initial treatment of overweight and obesity for adults with weight-related comorbidities and for those at high risk of complications, and as a component of first-line treatment for patients with obesity and overweight without comorbidities

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Absolute and relative loss of total lean body mass, assessed via DXA scan, is often used as surrogate endpoint for measuring the impact on muscle mass, despite its obvious limitations, e.g., including the weight of organs, bones, tissue and fluids in addition to muscle

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