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Room temperature or slightly warm water is less likely to trigger reflux than ice-cold water, which can cause stomach contractions

Effectiveness of surgical interventions for managing obesity in children and adolescents: a systematic review and meta-analysis framed using minimal important difference estimates based on grade guidance to inform a clinical practice guideline
As a large peptide hormone, insulin does not transfer significantly into breast milk, and any small amounts present would be digested in the infant's gastrointestinal tract

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This supports expanding its use to all overweight or obese patients with atherosclerotic cardiovascular disease, revising BMI-based prescription limits to focus on reducing cardiovascular risk, and positioning GLP-1RAs as an important part of secondary prevention for heart disease
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