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While challenges with adherence, side effects, and weight regain upon discontinuation have prompted the search for additional strategies, targets like GLP-1R, GIPR, and GDF8 (Myostatin) still remain the most highly relevant and active areas of research for developing effective obesity treatments

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President Trump announced drugmakers Novo Nordisk and Eli Lilly have agreed to lower the cost of their GLP-1 weight loss drugs, Wegovy and Zepbound.

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