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doi: 10.1016/j.lfs.2017.11.019

Semaglutide and tirzepatide reduced blood glucose by ~200 mg/dL and HbA1c by ~2% at 2 months, but their effects waned by the third month

Practical scenarios: when alternating might make sense Despite the limitations, there are specific situations where alternating between semaglutide and tirzepatide could be a reasonable approach

All patients assigned to BYETTA initially received 5 mcg BID for four weeks

Advise patients that changes in insulin regimen can predispose to hyperglycemia or hypoglycemia and that changes in insulin regimen should be made under close medical supervision [see Warnings and Precautions (5.2)]

Be sure to follow the recommended dosing on the label