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However, the FDA repeatedly stated it "cannot determine the adequacy" of many responses or found them "not adequate." Regulatory consequences FDA warned that "failure to adequately address this matter may result in regulatory action being initiated by the FDA without further notice

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This is in accordance with preclinical studies demonstrating the ventral tegmental area and NAc as key areas mediating the effects of GLP-1 receptor agonists on alcohol intake 10,18

[DOI] [PubMed] [Google Scholar] Werner U

The results showed that Tanzeum bound with slightly faster association and dissociation rates than GLP-1 WT, resulting in a 1.5-fold difference in binding affinity to the receptor (Tanzeum: 76.1 nM

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