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Description
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The efficacy and safety of oral semaglutide was assessed in the PIONEER clinical trial program, which included 9543 patients (1293 Japanese)
Technical breakdown
A patient experiencing significant tachycardia while on tirzepatide should discontinue the medication immediately if they have postural orthostatic tachycard...
This is largely driven by rapid gastric emptying and an exaggerated GLP-1 mediated insulin response, particularly after Roux-en-Y gastric bypass (RYGB)
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