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15 Although the primary function of GLP-1 is to serve as an anorexigenic (appetite-reducing) and incretin hormone, as well as a mediator of the ileal brake through inhibition of upper gastrointestinal function to prevent malabsorption and postprandial metabolic disturbances, the influence of GLP-1 on colon function was evaluated by a limited number of studies

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This pharmacokinetic difference has implications for clotting risk, blood clot concerns , and, as we will discuss in detail, drug absorption when combined with medications that slow your digestive system

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Published Phase 2 trial data for retatrutide (Jastreboff et al., NEJM , 2023) demonstrated significant reductions in body weight and improvements in cardiometabolic markers

(1) Even though the pain from plantar fasciitis can be extremely intense after rest, it usually eases during the day