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Introduction Both type 2 diabetes mellitus (T2DM) and dyslipidemia are individually associated with a cluster of risk factors of atherosclerosis

These data, together with the fact that acute administration of both semaglutide monotherapy or semaglutide in combination with BI8271 induced the same glycaemic regulation, make us conclude that glycaemic regulation per se may not be crucial in improving stroke recovery

Microbiota-derived metabolites, including short-chain fatty acids (SCFAs) and tryptophan-derived indoles, can modulate GLP-1 secretion, gutbrain communication, insulin sensitivity, and inflammatory tone ( This mini-review critically examines the mechanisms underlying GLP-1induced weight loss, the physiological limits of energy expenditure in humans, and the emerging evidence supporting postbiotics as complementary modulators within convergence-based strategies aimed at lean mass preservation and weight-loss sustainability