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Consistent with this, certain effectors of the Wnt pathway, including lithium and -catenin, enhance Gcg expression in intestinal but not pancreas-derived cell lines, supposedly via inhibition of the glycogen synthase kinase-3beta (GSK-3beta) [132,133]

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[DOI] [PubMed] [Google Scholar] 47.Heerspink H.J.L., Stefnsson B.V., Correa-Rotter R., Chertow G.M., Greene T., Hou F.-F., Mann J.F.E., McMurray J.J.V., Lindberg M., Rossing P., et al

However, several considerations cast doubt on the endocrine mechanism of the GLP-1