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Description

Given the low circulating and tissue levels of most DPP-4 substrates and the technical challenge inherent in quantifying intact versus cleaved peptides, it seems likely that some DPP-4 substrates currently classified as pharmacological may one day also be found to be cleaved by DPP-4 in vivo [20]

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The recently developed receptor agonists for glucagon-like peptide-1 (GLP-1RAs), stimulate insulin secretion and reduce glycated hemoglobin levels without having side effects such as weight gain and hypoglycemia