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Description
The precise mechanisms underlying headaches with GLP-1 receptor agonists are not fully understood, but several hypothetical pathways have been proposed

Metformin: This medication enhances insulin sensitivity while also suppressing appetite

Patients with a history of pancreatitis should discuss GLP-1 use carefully with their provider

The predominance of primary care prescribing suggests that the oral formulation may lower barriers to use outside of specialty care, aligning with its potential to broaden access to obesity treatment

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This is because better blood sugar control and weight loss can lead to fewer symptoms of type 2 diabetes, such as fatigue and frequent urination
