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Retatrutide uniquely stimulates three critical metabolic receptors simultaneouslyGLP-1, GIP, and glucagonmaking it significantly more effective than peptides targeting a single receptor

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Their dual mechanism may address key limitations of current pharmacotherapies

There is a unique opportunity for collaboration across specialties to raise awareness around the multiple benefits of GLP-1 RAs and determine the best care pathway to treat patients with PAD. With the ongoing PAD amputation and obesity epidemics, there is an opportunity to establish partnership and open communication between vascular surgeons and weight loss clinics to determine if a patient could benefit from GLP-1 RAs. i Molina CS, Faulk JB

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