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The highest maintenance dose tested was 12 mg weekly, administered subcutaneously in the abdomen or thigh using a standard auto-injector pen

Addictive substances typically cause supraphysiological dopamine release in the nucleus accumbens, reinforcing drug-seeking behaviour

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It was with the five-milligram dose, which is one of the lower doses of tirzepatide, Skelley says
Theoretical frameworks suggest starting tesamorelin at 1mg daily for 2 to 4 weeks before adding retatrutide, then escalating to the standard 2mg daily once tolerance is established

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Batsis J.A., Villareal D.T
