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Key operational steps include needle attachment (separate needles required), priming before each weekly injection, dose selection, injection technique (press and hold button for up to 10 seconds, listening for two clicks, confirming gray plunger visibility), and disposal (discard entire pen after 4th dose, needles in sharps container)

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There are also theoretical concerns about growth hormone's proliferative effects, though evidence linking physiological GH elevation to cancer risk in adults remains inconclusive

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Tirzepatide is administered as a subcutaneous injection once weekly, with dosing typically initiated at 2.5 mg for 4 weeks, then increased to 5 mg

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