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It's a fillip for new Novo Nordisk chief executive Mike Doustdar, who took the helm last year with a clear remit to defend the GLP-1-based weight loss and diabetes business from rivals like Eli Lilly, as well as knock-off versions of semaglutide that sidestep the company's intellectual property (IP).

Chronic knockdown of LH GLP-1R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight and ultimately resulted in a doubling of fat mass in males and females

Semaglutide for weight loss in non-diabetics has become an increasingly popular option for people struggling with obesity.

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