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For women in the U.S

3.2 Adipose tissue In humans, infusions of GIP(3-30)NH 2 during a hyperinsulinemic and hyperglycemic clamp reduce GIP-induced blood flow to subcutaneous adipose tissue and inhibit the increase in triacylglycerol clearance observed with GIP administration ( 2 increased free fatty acid (FFA) output and a higher FFA/glycerol-ratio, suggesting a reduction in in-situ re-esterification of FFA and lipolytic activity ( Nevertheless, GIP receptor antagonism is thought to exert beneficial metabolic effects due to the expression of GIP receptors on adipocytes (94), along with elevated circulating GIP levels observed in both individuals with obesity (95) and individuals given a high-fat-diet (96)

Month 1: Women : 1.5 mg once weekly Men : 1.8 mg once weekly Month 2: Women: 3 mg once weekly (compared to the standard 5 mg) Men : 3.6 mg once weekly (compared to the standard 5 mg) Month 3: Women : 4.5 mg once weekly (instead of the standard 7.5 mg) Men : 5.4 mg once weekly (instead of the standard 7.5 mg) Doses can be gradually increased while remaining below standard titration levels

Ill point out that there are many question marks on this slide as we know much less about amylin than we do GLP-1

All trials were of parallel group, double-blind design, and their mean duration ranged from 0.75 (SOLOIST-WHF) to 5.4 years (REWIND)

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