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This combination results in: Lower post-meal glucose spikes Improved insulin sensitivity Reduced appetite and caloric intake These effects make Tirzepatide more effective than traditional GLP-1 receptor agonists (like liraglutide and semaglutide), which only target one pathway

Ethics declarations Competing interests MV has within the last three years, served as consultant for Lundbeck, Eli Lilly and Johnson & Johnson

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J Pharmacol Exp Ther 363:92103