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Abbreviations BBB Bloodbrain barrier CNS Central Nervous System GFAP Glial fibrillary acidic protein GLP-1R Glucagon-like peptide-1 receptor HFD Highfat diet IB4 Biotinylated isolectin B4 Iba-1 Ionized calciumbinding adaptor molecule-1 ND Normolipid diet NVU Neurovascular unit SAL Saline solution SEMA Semaglutide Author contributions VE wrote the main manuscript

They can be worse in the morning or when lying down and may worsen with straining, coughing, or bending

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Phentermine suppresses appetite by increasing norepinephrine activity in the brain

Standard antibiotics work normally alongside GLP-1 therapy with no significant interactions

A total of 569 patients out of 8803 (6.5%) receiving semaglutide experienced this outcome as compared to 701 patients out of 8801 (8.0%) receiving placebo (between-group difference of 1.5%)