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Description
291 , R367R375 (2006)
Besemer F, Verschoor AJ, Diamant M, Hoogma RPLM
The changes allow stronger binding to albumin, slowing clearance and extending circulation
As hypothesized, this modification resulted in reduced internalization at the GLP-1R
The study noted a reduction in the dosage of acetazolamide, which was temporally correlated with the introduction of GLP-1 agonist therapy
Vahl TP, Paty BW, Fuller BD, Prigeon RL, DAlessio DA (2003) Effects of GLP-1-(736)NH2, GLP-1-(737), and GLP-1- (936)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans
