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Another human study demonstrated a slight decrease in energy expenditure, but this decrease is not proportional to the weight loss of the experimental group receiving GLP-1 agonists, suggesting that GLP-1 agonists can attenuate some of the decrease in energy expenditure expected with a decrease in weight [49]

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There were trends for significant interactions between diet and treatment (F( 1,54 ) = 10.746, R 2 = 0.036, p = 0.053), sex and treatment (F( 1,54 ) = 3.217, R 2 = 0.033, p = 0.053) and sex and diet (F( 1,54 ) = 2.970, R 2 = 0.033, p = 0.065)

Emphasize resistance training and body composition monitoring to address muscle loss risk and changing energy levels

you need water to smooth things over on the road, so to speak

Many insurance plans, employers, and community health organizations offer DPPs at low or no cost