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However, establishing causality in pharmacovigilance is inherently challenging, as temporal association does not prove causation

Administer within one hour prior to the first meal of the day

Although direct evidence for GLP-1RA use in PsA remains limited, the inclusion of PsA populations in these tirzepatide trials represents a conceptual shift toward testing immunometabolic interventions in inflammatory arthritis rather than restricting their evaluation to skin disease alone

Front Med Lausanne 10:1089099 Herrlinger KR, Stange EF (2023) Prioritization in inflammatory bowel disease therapy

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The deep short axon cells (dSACs) in the granule cell layer (GCL) of olfactory bulb, named PPG neurons, could synthesize and release GLP-1 and in turn modulate the activity of the first-order neurons, mitral cells (MCs) which are the primary projection neurons of the olfactory bulb ( via blocking voltage-dependent potassium channel reduces body weight in obese mice ( via inhibition of voltage-dependent potassium channel conductance and enhancement of glutamatergic neurotransmission, could lead to changed excitability of higher olfactory cortical as well as hypothalamic regions to change metabolic states